姓名：董井泉 性别：男

  职称：校聘副教授

  职务：硕士生导师

  学历学位：博士研究生

本人简介：

2010年6月毕业于东北农业大学动物医学院动物药学专业，获农学学士学位；

2014年6月毕业于东北农业大学动物医学院预防兽医专业，获农学硕士学位；

2018年6月毕业于吉林大学动物医学院预防兽医专业，获农学博士学位；

2018年7月至今，在江苏海洋大学药学院工作。

董井泉，中共党员，博士研究生，江苏海洋大学药学院硕士生导师，参加国家973计划项目，主持江苏省科技厅面上项目。主要从事微生物感染与天然免疫研究、免疫药理学与信号转导通路研究、生态毒理与公共卫生学研究、等温扩增的体外诊断技术及基于CRISPR/Cas9的基因编辑技术的研究，发表SCI学术论文累计影响因子120.21。曾获“第三届中国创新挑战赛（连云港）”优胜奖和江苏省科技副总。

课程教学：

体外诊断技术、现代制药工艺学、分子免疫学、分子病毒学

主要研究方向介绍：

（1）微生物感染与天然免疫研究。主要包括常见海洋微生物、食品微生物等造成哺乳动物免疫损伤，解析损伤机制，为组织损伤的免疫学防治提供策略。

（2）免疫药理学与信号转导通路研究。主要包括天然结构化合物（中药单体）对先天免疫信号转导的调控机制研究，筛选药物靶点、解析药理学机制，为重要疾病防治提供候选药物。

（3）生态毒理与公共卫生学研究。主要包括环境主要环境中农药残留、抗寄生虫药等造成水生动物及哺乳动物营养代谢障碍、组织免疫损伤及免疫学防治研究。

（4） 等温扩增的体外诊断技术及基于CRISPR/Cas9的基因编辑技术。主要包括基于RPA技术的重要病原微生物诊断和基于CRISPR/Cas9的基因编辑技术解析重要病原微生物致病机制的研究。

代表性成果：

【微生物感染与天然免疫研究方向】

1. Yu G, Zhang W, Wang J, Yang Q, Wang L, Bello B, Zhao P*, Dong J*. Vibrio harveyi infections induce production of proinflammatory cytokines in murine peritoneal macrophages via activation of p38 MAPK and NF-κB p65 pathways mediated by TLR2, but reversed by PI3K/AKT pathways. Developmental and Comparative Immunology. 2022 Feb, 127:104292, doi: 10.1016/j.dci.2021.104292. 中科院一区top期刊，IF:3.636. 通讯作者.

2. Wang J, Zhang W, Yu G, Yang Q, Wang L, Bello B, Dong J*, Liu G*, Zhao P*. Activation of TLR2-mediated NF-κB, MAPK, AKT signaling pathways is responsible for Vibrio alginolyticus triggered inflammatory response in vitro. Microbial Pathogenesis, 2022 Jan, 162:105219, doi: 10.1016/j.micpath.2021.105219. 中科院三区，IF:3.738. 通讯作者.

3. Yu G, Wang J, Zhang W, Yang Q, Liu G, Wang L, Bello B, Zhang X, Zhang T, Fan H, Zhao P*, Liang W*, Dong J*. NLRP3 inflammasome signal pathway involves in Vibrio harveyi induced inflammatory response in mouse peritoneal macrophages. Acta Biochimica et Biophysica Sinica. 2021 Dec 8, 53(12):1590-1601, doi: 10.1093/abbs/gmab137. 中科院二区，IF：3.848. 通讯作者.

4. Wang J, Ding Q, Yang Q, Fan H, Yu G, Zhang W, Bello B, Zhang X, Zhang T, Dong J*, Liu G*, Zhao P*. Vibrio alginolyticus triggers inflammatory response in mouse peritoneal macrophages via activation of NLRP3 inflammasome. Frontiers in Cellular and Infection Microbiology, 2021 Nov, 15;11:769777, doi: 10.3389/fcimb.2021.769777. 中科院二区，IF:5.293. 通讯作者.

5. Zhang W, Bello B, Yang H, Liu G, Wang G, Li Z, Guo T, Zhao P*, Dong J*. Aeromonas sobria regulates proinflammatory immune response in mouse macrophages via activating the MAPK, AKT, and NF-κB pathways. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) . 2021 Sept 15, 22(9):782-790, doi: 10.1631/jzus.B2100456. 中科院二区，IF：3.066. 通讯作者.

6. Zhang W, Li Z, Yang H, Wang G, Liu G, Wang Y, Bello B, Zhao P*, Liang W*, Dong J*. Aeromonas sobria induces proinflammatory cytokines production in mouse macrophages via activating NLRP3 inflammasome signaling pathways. Frontiers in Cellular and Infection Microbiology. 2021 Aug 26, 11:691445, doi: 10.3389/fcimb.2021.691445. 中科院二区，IF：5.293. 通讯作者.

   【免疫药理学与信号转导通路研究方向】

7. Zhang T, Wang K, Fan H, Yang Q, Zhang X, Liu F, Feng X, Chen Y, Teng D, Zhao P*, Dong J*. Ameliorative effect of scutellarin on acute alcohol brain injury in mice. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) . 2022 Mar, doi: 10.1631/jzus.B2100763. 中科院二区，IF:3.066. 通讯作者.

8. Fan H, Tu T, Zhang X, Yang Q, Wang J, Liu G, Zhang T, Zhang W, Dong Z, Dong J*, Zhao P*. Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice. Food and Chemical Toxicology. 2022 Jan, 159:112759, doi: 10.1016/j.fct.2021.112759. 中科院一区 top 期刊，IF:6.023. 通讯作者.

   【生态毒理与公共卫生学研究方向】

9. Dong J, Zhang N, Zhao P, Li J, Wang X, Li X, Gong P*, Zhang X*. GRA12, a novel dense granule protein from Neospora caninum. Parasitology International. 2021 Apr, 81:102268, doi: 10.1016/j.parint.2020.102268. 中科院三区，IF:2.23. 第一作者.

10. Dong J, Zhang N, Zhao P, Li J, Cao L, Wang X, Li X, Yang J, Zhang X*, Gong P*. Disruption of dense granular protein 2 (GRA2) decreases the virulence of Neospora caninum. Frontiers in Veterinary Science. 2021 Feb 19, 8:634612, doi: 10.3389/fvets.2021.634612. 中科院二区，IF:3.412. 第一作者.

11. Yu G, Liang W, Yang Q, Wang J, Wang Y, Zhang T, Zhang X, Fan H, Zhao P*, Cao L*, Dong J*. Immune protective evaluation elicited by DNA vaccination with Neospora caninum dense granules proteins in mice. Frontiers in Veterinary Science. 2021 Feb, 26;8:638067, doi: 10.3389/fvets.2021.638067. 中科院二区，IF:3.412. 通讯作者.

12. Wang W, Gong P, Wang P, Dong J, Wang X, Yang Z, Li J, Zhang X*. A novel dense granule protein NcGRA23 in Neospora caninum. Acta Biochimica Et Biophysica Sinica. 2018 Jul 1, 50(7):727-729, doi: 10.1093/abbs/gmy054. 中科院二区，IF:3.848.

13. Dong J, Li J, Wang X, Yang J, Gong P, Zhang X*. A karyozoic phenomenon for Neospora caninum. Acta Biochimica Et Biophysica Sinica. 2018 Mar 1, 50(3):313-315, doi: 10.1093/abbs/gmx145. 中科院二区，IF:3.848. 第一作者.

14. Dong J, Li J, Wang J, Li F, Yang J, Gong P, Li H, Zhang X*. Identification and characterization of GRA6/GRA7 of Neospora caninum in MDBK cells. Acta Biochimica Et Biophysica Sinica. 2017 Apr 1, 49(4):361-366, doi: 10.1093/abbs/gmx010. 中科院二区，IF:3.848. 第一作者.

15. Zhao P†, Dong J†, Cao L†, Li J, Zhang X, Li X, Wang X, BK Bello, Zhang N*, Gong P*. A newly discovered dense granule protein 3 in Neospora caninum. Acta Parasitologica. 2021 Dec, 66(4):1581-1585, doi: 10.1007/s11686-021-00402-7. 中科院四区，IF:1.44. 第一作者.

16. Zhao P†, Zhang N†, Dong J†, Li J, Wang X, Li X, Li X, Yang J, Gong P*, Zhang X*. Effects of dense granular protein 6 (GRA6) disruption on Neospora caninum virulence. Frontiers in Veterinary Science. 2020 Sep 22, 7:562730, doi: 10.3389/fvets.2020.562730. 中科院二区，IF:3.412. 第一作者.

17. Zhao P, Cao L, Wang X, Li J, Dong J, Zhang N, Li X, Li S, Sun M, Zhang X, Liang M, Pu X, Gong P*. Giardia duodenalis extracellular vesicles regulate the proinflammatory immune response in mouse macrophages in vitro via the MAPK, AKT and NF-κB pathways. Parasites & Vectors. 2021 Jul 8, 14(1):358, doi: 10.1186/s13071-021-04865-5. 中科院一区 top 期刊，IF:3.876.

18. Zhao P, Cao L, Wang X, Dong J, Zhang N, Li X, Li J, Zhang X, Gong P*. Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways. Plos Neglected Tropical Diseases. 2021 Apr 2, 15(4):e0009304, doi: 10.1371/journal.pntd.0009304. 中科院 一区 top 期刊，IF:4.411.

19. Pan L, Gong P, Wang X, Dong J, Yang J, Li J, Zhang X*. The expressive identification and localization of bicoid-interacting protein 3 in the toxoplasma gondii Chinese I genotype Wh3 strain. Acta Tropica. 2019 Sep, 197:105040, doi: 10.1016/j.actatropica.2019.05.031. 中科院三区，IF:3.112.

    【等温扩增的体外诊断技术及基于CRISPR/Cas9的基因编辑技术研究方向】

20. Yang X, Zhao P, Dong Y, Chen S, Shen H, Jiang G, Zhu H, Dong J*, Gao S*. An isothermal recombinase polymerase amplification (RPA) combined lateral flow strip (LFS) method for rapid on-site detection of Vibrio vulnificus in raw seafood. Food microbiology. 2021 Sep, 98:103664, doi: 10.1016/j.fm.2020.103664. 中科院一区 top 期刊，IF:5.516. 通讯作者.

21. Yang H, Wang Y, Yang Q, Fan H, Wang L, Zhang T, Li Z, Liu G, Zhao P, Wu H*, Dong J*, Liang W*. A Rapid and Sensitive Detection Method for Pseudomonas aeruginosa using Visualized Recombinase Polymerase Amplification and Lateral Flow Strip Technology. Frontiers in Cellular and Infection Microbiology, 2021 Sep 14, 11:698929. doi: 10.3389/fcimb.2021.698929. 中科院二区，IF:5.293. 通讯作者.

22. Yang X, Dong Y, Ma C, Qiao Y, Jiang G, Chen S, Dong J*, Shen H*, Gao S*. Establishment of a visualized isothermal nucleic acid amplification method for on-site diagnosis of acute hepatopancreatic necrosis disease in shrimp farm. Journal of Fish Diseases. 2021 Sep, 44(9):1293-1303, doi: 10.1111/jfd.13388. 中科院二区，IF:2.767. 通讯作者.

23. Wang J, Tang W, Chen S, Zhang J, Ji J, Dong J*, Liu G*, Gao S*. Rapid and sensitive detection of Vibrio alginolyticus pathogenic strains by real-time recombinase polymerase amplification. Acta Biochimica et Biophysica Sinica. 2021 Jul 5, 53(7):950-954, doi: 10.1093/abbs/gmab051. 中科院二区，IF:3.848. 通讯作者.

24. Yu H, Yang X, Zhang J, Yang H, Zhao P, Shen H, Jiang G, Ji J*, Dong J*, Gao S*. A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp. Acta Biochimica et Biophysica Sinica. 2021 Mar 2, 53(3):381-384, doi: 10.1093/abbs/gmaa175. 中科院二区，IF:3.848. 通讯作者.

25. Ma C, Fan S, Wang Y, Yang H, Qiao Y, Jiang G, Lyu M, Dong J*, Shen H*, Gao S*. Rapid detection of Enterocytozoon hepatopenaei infection in Shrimp with a real-time isothermal recombinase polymerase amplification assay. Frontiers in Cellular and Infection Microbiology. 2021 Feb 25, 11:631960, doi: 10.3389/fcimb.2021.631960. 中科院二区，IF:5.293. 通讯作者.

26. Yang X, Zhang X, Wang Y, Shen H, Jiang G, Dong J*, Zhao P*, Gao S*. A real-time recombinase polymerase amplification method for rapid detection of Vibrio vulnificus in seafood. Frontiers in Microbiology. 2020 Nov 6, 11:586981, doi: 10.3389/fmicb.2020.586981. 中科院二区 top 期刊，IF:5.64. 通讯作者.

27. Yang X, Zhao P, Dong Y, Shen X, Shen H, Li J, Jiang G, Wang W, Dai H, Dong J*, Gao S*, Si X*. An improved recombinase polymerase amplification assay for visual detection of Vibrio parahaemolyticus with lateral flow strips. Journal of Food Science, 2020 Jun, 85(6):1834-1844. doi: 10.1111/1750-3841.15105. 中科院三区，IF:3.167. 通讯作者.

28. Wu H, Zhao P, Yang X, Li J, Zhang J, Zhang X, Zeng Z, Dong J*, Gao S*, Lu C*. A Recombinase Polymerase Amplification and Lateral Flow Strip Combined Method That Detects Salmonella enterica Serotype Typhimurium With No Worry of Primer-Dependent Artifacts. Frontiers in Microbiology, 2020 Jun 23, 11:1015, 11:1015. doi: 10.3389/fmicb.2020.01015. 中科院二区 top 期刊，IF:5.64. 通讯作者.

29. Dong Y, Zhao P, Chen L, Wu H, Si X, Shen X, Shen H, Qiao Y, Zhu S, Chen Q, Jia W, Dong J*, Li J*，Gao S*. Fast, simple and highly specific molecular detection of Vibrio alginolyticus pathogenic strains using a visualized isothermal amplification method. BMC Veterinary Research, 2020 Mar 4, 16(1):76. doi: 10.1186/s12917-020-02297-4. 中科院二区，IF:2.741. 通讯作者.

30. Wang L, Zhao P, Si X, Li J, Dai X, Zhang K*, Gao S*, Dong J*. Rapid and specific detection of Listeria monocytogenes with an isothermal amplification and lateral flow strip combined method that eliminates false positive signals from primer-dimers. Frontiers in Microbiology, 2020 Feb 6, 10:2959. doi: 10.3389/fmicb.2019.02959. 中科院二区 top 期刊，IF:5.64. 通讯作者.

     

    联系方式：

    电子邮箱：2018000029@jou.edu.cn

    电 话：0518-85586628

    （2022年2月更新）