姓名：郝超
性别：男
职称：校聘副教授
职务：硕士生导师
学历学位：博士研究生
本人简介：
学习经历
2007-09 ~ 2011-07 济南大学 学士 材料化学
2011-09 ~ 2014-06 辽宁大学 硕士 有机化学
2018-09 ~ 2022-09华中科技大学 博士 生物医学工程
☆ 工作经历
2022-10~至今 江苏海洋大学 药学院 校聘副教授
2014-07 ~ 2020-11 江苏恩华药业股份有限公司 恩华药物研究院
2017-10 ~ 2018-05 清华大学药学院 钱峰课题组交流学习
郝超，博士研究生，毕业于华中科技大学生物医学工程专业，江苏海洋大学药学院校聘副教授、硕士生导师。擅长固体口服制剂、纳米晶制剂、复方制剂开发、药物晶体学、药物共晶研究、工业结晶。湖北省科技进步三等奖 第三完成人；以第一作者和通讯作者在EJMC/IJP/JPS等国内外杂志发表文章10余篇，申请发明专利20余项，其中授权国内专利10余项，授权PCT专利3项；无效专利1项。
擅长教学：
《药用高分子材料》
主要研究方向介绍：
1. 晶态药物：药物晶型、药物共晶（药物溶解性能调制）
2. 高端载药制剂：纳米制剂、缓控释制剂、粘膜给药制剂。
3. 改良型新药：口服液、口崩片、长效制剂等
主要研究项目：
基于黄酮类配体的长时缓释药物共晶的机制及应用研究，江苏海洋大学人才引进科研基金项目，2023-2025年，项目负责人
代表性成果：
【期刊论文】
1. Hao Chao#, Chen Yin#, Xiong Jiaying, Yang Zhengge, Gao Lanchang, Liu Bi-Feng, Liu Xin, Jin Jian* and Zhang Guisen* Polymorphs and pharmacokinetics of an antipsychotic drug candidate. International Journal of Pharmaceutics. 2020,586,119600.（IF=6.510）
2. Duan, Chenxin, Liu, Wenwen, Tao, Yunwen, Liang, Feifei, Chen, Yanming, Xiao, Xinyi, Zhang Guisen，Chen Yin*, Hao Chao* (共通讯作者). Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate. Pharmaceutics, 2022. 14(1).(IF=6.525)
3. Jiaying Xiong, Tao Zhuang, Yurong Ma, Junyi Xu, Jiaqi Ye, Ru Ma, Shuang Zhang, Xin Liu, Bi-Feng Liu, Chao Hao*(共通讯作者), Guisen Zhang*, Yin Chen*. Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain, European Journal of Medicinal Chemistry, 2021,113879 （IF：7.088）
4. Hao Chao#, Jin Jian#, Xiong Jiaying, Yang Zhengge, Gao Lanchang, Ma Yanqin, Liu Bi-Feng, Liu Xin, Chen Yin* and Zhang Guisen*. Polymorphs of DP-VPA solid solutions and their physicochemical properties. Journal of Pharmaceutical Sciences. 2020, 109(7),2156-2165. （IF：3.784）
5. Zhengge Yang, Ru Ma, Yin Chen, Yifang Zhang, Xin Liu, Bi-Feng Liu, Guisen Zhang*,Chao Hao* (共通讯作者), Drug-drug eutectic mixtures of celecoxib with tapentadol and milnacipran which could improve analgesic and antidepressant efficacy, Journal of Drug Delivery Science and Technology, 2022, 67, 102995.(IF=5.062)
6.Gao Lanchang#, Hao Chao#（共一）, Ma Ru, Chen Jiali, Zhang Guisen, Chen Yin *. Synthesis and biological evaluation of a new class of multi-target heterocycle piperazine derivatives as potential antipsychotics. RSC Advances. 2021, 11, 16931-16941. （IF：4.036）
7. Liu Wenwen, Ma Ru, Liang Feifei, Duan Chenxin, Zhang Guisen, Chen Yin*; Hao Chao*(共通讯作者). New cocrystals of antipsychotic drug aripiprazole: decreasing the dissolution through cocrystallization. Molecules. 2021, 26(9), 2414 （IF：4.927）
8. Liang, Feifei, Tan, Xiaofang, Hao, Shuaishuai, Liu, Wenwen, Duan, Chenxin, Zhang Guisen*, Hao Chao* (共通讯作者). Synthesis and structural characterization of two novel olanzapine cocrystals with decreased or enhanced dissolution rate. Journal of Molecular Structure, 2022,1255, 132340（IF=3.841）
9. Chenxin Duan, Yanming Chen, Yuxin Zhang, Feifei Liang, Wenwen Liu, Xinyi Xiao, Cangcang Xu, Tao Zhuang*, Chao Hao*(共通讯作者), and Yin Chen*; Two Cocrystals of Olaparib with Flavonoids toward Sustained Release: Structure, Dissolution Behavior, and Anticancer Activity Analysis, Crystal Growth&Design, 2022. 22(8), 4885-4894（IF=4.010）
10. Jin Jian #, Zhang Kunxiao #, Dou Fei #, Hao Chao, Zhang Yifang, Cao Xudong, Gao Lanchang, Xiong Jiaying, Liu Xin, Liu Bi-Feng, Zhang Guisen* and Chen Yin* . Isoquinolinone derivatives as potent CNS multi-receptor D2/5-HT1A/5-HT2A/5-HT6/ 5-HT7 agents: Synthesis and pharmacological evaluation. European Journal of Medicinal Chemistry. 2020. 207, 112709.
11. Xiong Jiaying, Jin Jian, Gao Lanchang, Hao Chao, Liu Xin, Liu Bi-Feng, Chen Yin* and Zhang Guisen*. Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain. European Journal of Medicinal Chemistry. 2020, 191,112144.
12. Gao Lanchang, Hao Chao, Chen Jiali, Ma Ru, Zheng Lu, Wu Qingkun, Liu Xin, Liu Bi-Feng, Zhang Guisen, Chen Yin*, Jian Jin*. Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect. Bioorganic & Medicinal Chemistry Letters. 2021, 40, 127909
13. 郝超，陈亮，王国海，张桂森，盐酸美利曲辛多晶型的制备与表征. 中国医药工业杂志, 2017, 48(10): 1508-1512.
14. 郝超, 王国海, 陈亮, 张巍, 曹龙吉, 张桂森. 一种盐酸卡利拉嗪的新晶型. 中国医药工业杂志, 2018, 6: 830-834.
【申请专利】
1. Hao Chao. Crystalline form of propanamide derivative and preparation method there for. WO2020114514（已授权）
2. 郝超，刘文文，陈寅，张桂森； 一种阿立哌唑药物共晶及其制备方法. CN113105389（已授权）
3. 郝超，杨正格，陈寅，金牮，张桂森；塞来昔布和盐酸米那普仑低共熔混合物、含其的药物组合物及其制备方法和应用. CN112870205
4. Hao Chao, Ma Yanqin, Wang Yong; Zhou Yingzhen, Chen Liang；Crystal form of phospholipid derivative of valproic acid and preparation method there for. WO2019206266（已授权）
5. Li Qingeng, Duan Chen; Wang Tao, Liao Jian, Li Changwen, Hao Chao; Benzodiazepine derivative hydrochloride and crystal form, preparation method, and application there of. WO 2019158075
6. 郝超，马彦琴，王勇，周英珍，陈亮，张桂森; 1-硬脂酰-2-丙戊酰-sn-甘油-3-磷脂酰胆碱的多晶型物及制备方法，CN108659038（已授权）
联系方式：
电子邮箱：D201880507@hust.edu.cn
（2023年3月更新）
